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Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

Gastroparesis: what is the current state-of-the-art for evaluation and medical management? What are the results?


PMID 23801519

Abstract

Gastroparesis is a chronic motility disorder that leads to delayed gastric emptying and negatively impacts morbidity, mortality, and quality of life. This paper provides an overview of the pathophysiology leading to symptoms in gastroparesis, discusses tests for diagnosis, and examines the evidence behind different treatment options for gastroparesis. Although delayed gastric emptying is the cardinal finding in gastroparesis, other physiologic abnormalities may contribute to the pathogenesis of symptoms. Gastric emptying scintigraphy is considered the gold standard for the diagnosis of gastroparesis but novel tests are currently available. Although metoclopramide is the only FDA approved medication to treat gastroparesis, alternative therapeutic options are available and should be tailored according to symptoms as well as physiologic abnormalities.

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1440808 Metoclopramide hydrochloride, United States Pharmacopeia (USP) Reference Standard
C14H22ClN3O2 · HCl · H2O