EMAIL THIS PAGE TO A FRIEND

Chirurgie de la main

[Treatment of Dupuytren's contracture by collagenase injection].


PMID 23856551

Abstract

Dupuytren's disease is a disorder of the palmar aponeurosis responsible for apparition of pathological collagen cords that will gradually lead to a digital retraction. These cords cause functional disability to the hand with a real handicap for the patient. No curative treatment exists currently in this disease. Injections of collagenase from Clostridium histolyticum cause lysis of the collagen present in the cords and cause an interruption of the palmar cord. It is a new treatment in the management of Dupuytren's disease. The use of collagenase injection in the treatment of palmar form of Dupuytren's disease gives good results in the short and medium terms. It is a simple, minimally invasive treatment, several studies have proven its effectiveness and it approximates percutaneous needle fasciotomy in its easy use and its indications. Patients should be well informed about local reactions and transient pain with the injection of C. histolyticum collagenase. Diffusion of this technique is still limited by: the assessment of its cost compared to that of other methods of treatment and particularly the needle fasciotomy, and the evaluation of results over the long-term.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

C6079 Collagenase + protease inhibitor, 2-5 FALGPA units/mg solid, ≥800 CDU/mg solid, Suitable for isolation of rat pancreatic islet cells.
C1639
Collagenase from Clostridium histolyticum, sterile-filtered, for general use, Type I-S, 0.2-1.0 FALGPA units/mg solid, ≥125 CDU/mg solid
C5894
Collagenase from Clostridium histolyticum, sterile; sterile-filtered, Type IA-S, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid
C9722
Collagenase from Clostridium histolyticum, lyophilized powder (from sterile-filtered solution), 0.5-5.0 FALGPA units/mg solid, cell culture tested
C1764
Collagenase from Clostridium histolyticum, sterile-filtered, release of physiologically active rat epididymal adipocytes tested, Type II-S, 0.5-5.0 FALGPA units/mg solid
C1889
Collagenase from Clostridium histolyticum, sterile-filtered, release of physiologically active rat hepatocytes tested, Type IV-S, 0.5-5.0 FALGPA units/mg solid, ≥125 CDU/mg solid
C2014
Collagenase from Clostridium histolyticum, sterile-filtered, suitable for release of physiologically active rat pancreatic islets, Type V-S, ≥1 FALGPA units/mg solid, ≥125 CDU/mg solid
C9407
Collagenase from Clostridium histolyticum, powder, Suitable for the digestion and isolation of physiologically active pancreatic islet cells, suitable for cell culture
C9697
Collagenase from Clostridium histolyticum, lyophilized powder (from sterile-filtered solution), Suitable for digestion and isolation of physiologically active pancreatic islet cells, suitable for cell culture
C0255
Collagenase from Clostridium histolyticum, purified by chromatography, ≥1 FALGPA units/mg solid, ≥250 CDU/mg solid (CDU = collagen digestion units), lyophilized powder
C0773
Collagenase from Clostridium histolyticum, high purity, purified by chromatography, Type VII, ≥4 FALGPA units/mg solid, lyophilized powder, 1,000-3,000 CDU/mg solid (CDU = collagen digestion units)
C2399
Collagenase from Clostridium histolyticum, sterile-filtered, high purity, purified by chromatography, Type VII-S, ≥4 FALGPA units/mg solid, 1,000-3,000 CDU/mg solid
C2799
Collagenase from Clostridium histolyticum, powder, suitable for cell culture, 1000-3000 CDU/mg solid (CDU = collagen digestion units), ≥4 FALGPA units/mg solid, high purity
C8051
Collagenase from Clostridium histolyticum, Sigma Blend Type H, ≥1.0 FALGPA units/mg solid
C7926
Collagenase from Clostridium histolyticum, Sigma Blend Type F, ≥2.0 FALGPA units/mg solid