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Chemical communications (Cambridge, England)

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine.


PMID 23863949

Abstract

A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.

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