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Journal of nanoscience and nanotechnology

Catalytic activity of (Fe2O3)-MCM-41-nPrNH2 magnetically recoverable nanocatalyst for the synthesis of phenylpyrido[4,3-d]pyrimidins.


PMID 23901512

Abstract

A new series of phenylpyrido[4,3-d]pyrimidin-2-amin derivatives have been synthesised from the reaction of (E)-3,5-bis(benzylidene)-4-piperidones and guanidine carbonate in the presence of (Fe2O3)-MCM-41-nPrNH2 as a magnetically recoverable nanocatalyst under solvent free conditions. This catalyst was highly recyclable (up to 5 times) and was easily recovered from the reaction mixture using an external magnet without loss of activity. The prepared magnetic catalyst is characterized by Fourier transform infrared (FT-IR), X-ray powder diffraction (XRD), and nitrogen physisorption measurements. Also all the structures of title compounds 3a-h were elucidated by comprehensive 1H NMR, 13C NMR, IR and Mass spectra.