EMAIL THIS PAGE TO A FRIEND

Environmental toxicology

Indium chloride-induced micronuclei via reactive oxygen species in Chinese hamster lung fibroblast V79 cells.


PMID 24022999

Abstract

We study the cytotoxicity of indium chloride (InCl₃) in Chinese hamster lung fibroblasts, the V79 cells, using MTT assay. The results showed that InCl₃ did not induce significant cytotoxicity at various concentrations tested. In addition, the frequency of micronuclei (MN) was assayed to evaluate the genotoxic effects of InCl₃ in V79 cells. InCl₃ at concentrations ranged 0.1-1 μM significantly increased MN frequency in a concentration-dependent manner. Both catalase and superoxide dismutase at concentrations of 75 and 150 μg/mL significantly inhibited InCl₃-induced MN. Similarly, Germanium oxide (GeO₂) and dimercaprol expressed antigenotoxic effects. From these findings, it is concluded that InCl₃ is a potent genotoxic chemical, which may be mediated partly by inducing oxidative stress. The significance of this study shows that the workers in the semiconductor factories should be cautious in exposing to the hazardous genotoxic InCl₃.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

483702
Germanium(IV) oxide, ≥99.99% trace metals basis
GeO2
483001
Germanium(IV) oxide, powder, 99.999% trace metals basis
GeO2
199478
Germanium(IV) oxide, (crystalline powder), 99.998% trace metals basis
GeO2
57083
Indium, bars, 99.95%
In
264113
Indium, beads, diam. 2-5 mm, 99.999% trace metals basis
In
326607
Indium, beads, diam. 2-5 mm, ≥99.9% trace metals basis
In
357278
Indium, foil, thickness 1.0 mm, 99.999% trace metals basis
In
326631
Indium, foil, thickness 0.5 mm, 99.999% trace metals basis
In
357286
Indium, foil, thickness 0.5 mm, 99.99% trace metals basis
In
264040
Indium, foil, thickness 0.25 mm, 99.995% trace metals basis
In
357294
Indium, foil, thickness 0.25 mm, 99.99% trace metals basis
In
264059
Indium, foil, thickness 0.127 mm, 99.99% trace metals basis
In
357308
Indium, foil, thickness 0.1 mm, ≥99.995% trace metals basis
In
326615
Indium, pieces, 99.99% trace metals basis
In
203432
Indium, powder, −60 mesh, 99.999% trace metals basis
In
264032
Indium, powder, −100 mesh, 99.99% trace metals basis
In
277959
Indium, powder, 99.99% trace metals basis
In
385379
Indium, rod, diam. 10 mm, 99.9998% trace metals basis
In
264091
Indium, rod, diam. 6 mm, ≥99.999% trace metals basis
In
357065
Indium, wire, diam. 2.0 mm, 99.995% trace metals basis
In
340863
Indium, wire, diam. 1.5 mm, 99.99% trace metals basis
In
357073
Indium, wire, diam. 1.0 mm, 99.995% trace metals basis
In
264075
Indium, wire, diam. 1.0 mm, 99.99% trace metals basis
In
264067
Indium, wire, diam. 0.5 mm, 99.995% trace metals basis
In
326623
Indium, wire, diam. 0.25 mm, 99.999% trace metals basis
In
429414
Indium(III) chloride, anhydrous, powder, ≥99.999% trace metals basis
Cl3In
203440
Indium(III) chloride, 99.999% trace metals basis
Cl3In
334065
Indium(III) chloride, 98%
Cl3In
57110
Indium(III) chloride hydrate, ~39% indium basis, 2-3 mol/mol water
Cl3In · xH2O