EMAIL THIS PAGE TO A FRIEND

Clinical nutrition (Edinburgh, Scotland)

Magnesium-deficient high-fat diet: effects on adiposity, lipid profile and insulin sensitivity in growing rats.


PMID 24182515

Abstract

To determine if magnesium deficiency aggravates the effects of a high-fat diet in growing rats in terms of obesity, lipid profile and insulin resistance. The study population comprised 48 newly weaned male Wistar Hannover rats distributed into four groups according to diet, namely, control group (CT; n = 8), control diet provided ad libitum; pair-feeding control group (PF; n = 16), control diet but in the same controlled amount as animals that received high-fat diets; high-fat diet group (HF; n = 12), and magnesium-deficient high-fat diet group (HFMg(-); n = 12). The parameters investigated were adiposity index, lipid profile, magnesium status, insulin sensitivity and the phosphorylation of proteins involved in the insulin-signaling pathway, i.e. insulin receptor β-subunit, insulin receptor substrate 1 and protein kinase B. The HF and HFMg(-) groups were similar regarding gain in body mass, adiposity index and lipid profile, but were significantly different from the PF group. The HFMg(-) group exhibited alterations in magnesium homeostasis as revealed by the reduction in urinary and bone concentrations of the mineral. No inter-group differences were observed regarding glucose homeostasis. Protein phosphorylation in the insulin-signaling pathway was significantly reduced in the high-fat groups compared with the control groups, demonstrating that the intake of fat-rich diets increased insulin resistance, a syndrome that was aggravated by magnesium deficiency. Under the experimental conditions tested, the intake of a magnesium-deficient high-fat diet led to alterations in the insulin-signaling pathway and, consequently, increased insulin resistance.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

01700
Acrylamide, purum, ≥98.0% (GC)
C3H5NO
01696
Acrylamide, for Northern and Southern blotting, powder blend
C3H5NO
08267
Acrylamide, certified reference material, TraceCERT®
C3H5NO
23701
Acrylamide, analytical standard
C3H5NO
01697
Acrylamide solution, 40% in H2O, for molecular biology
C3H5NO
261130
Lanthanum, ingot (under oil), 99.9% trace rare earth metals basis
La
263117
Lanthanum, pieces
La
263109
Lanthanum, powder, −40 mesh, under oil, 99.9% trace rare earth metals basis
La
GF13609111
Lanthanum, foil, 25x25mm, thickness 0.125mm, as rolled, 99%
La
GF54212914
Lanthanum, foil, not light tested, 100x100mm, thickness 0.025mm, as rolled, 99%
La
GF43011391
Lanthanum, foil, 100x100mm, thickness 0.125mm, as rolled, 99%
La
GF15415691
Lanthanum, foil, 100x100mm, thickness 0.1mm, as rolled, 99%
La
GF09165786
Lanthanum, foil, 25x25mm, thickness 0.1mm, as rolled, 99%
La
GF88400189
Lanthanum, foil, 29x33mm, thickness 0.5mm, as rolled, 99%
La
GF60507019
Lanthanum, rod, 50mm, diameter 6.35mm, cast, 99%
La
GF76465176
Lanthanum, foil, 50x50mm, thickness 0.125mm, as rolled, 99%
La
GF45723326
Lanthanum, foil, 50x50mm, thickness 0.1mm, as rolled, 99%
La
GF90307144
Lanthanum, foil, not light tested, 25x25mm, thickness 0.025mm, as rolled, 99%
La
GF35079554
Lanthanum, foil, not light tested, 50x50mm, thickness 0.025mm, as rolled, 99%
La
GF63377017
Lanthanum, rod, 100mm, diameter 6.35mm, cast, 99%
La
GF16232295
Lanthanum, foil, 35x47mm, thickness 0.5mm, as rolled, 99%
La
16355
Nitric acid concentrate, 0.1 M HNO3 in water (0.1N), eluent concentrate for IC
HNO3
P8010
Sodium pyrophosphate tetrabasic, ≥95%
Na4O7P2