The American journal of the medical sciences

Inverse correlation between circulating endothelial progenitor cells with CD34+CD133+ and the severity of coronary atherosclerosis assessed by Syntax score.

PMID 24335569


The number of endothelial progenitor cells (EPCs) descends when atherosclerosis developed. The objective was to compare the number of CD34(+)CD133(+) cells with the severity of atherosclerosis assessed by Syntax score. The study included 80 patients with stable angina undergoing coronary angiography. Patients were classified into single-vessel group, multiple-vessel group and normal group according to angiography. The percentage of CD34(+)CD133(+) cells in the mononuclear cells isolated from peripheral blood of different groups by flow cytometric analysis was compared. The quantity of CD34(+)CD133(+) EPCs was log transformed to improve normality (lgEPC). Syntax score was used in this study to assess the extent of coronary artery disease. The level of lgEPC was lower in the single-vessel group than that in the normal group (-3.42 ± 0.44 versus -3.17 ± 0.39, P < 0.05), and the level of lgEPC was lower in the multiple-vessel group than that in the single vessel group (-3.63 ± 0.31 versus -3.42 ± 0.44, P < 0.05). An inverse correlation between lgEPC and Syntax score analyzed by linear regression. EPC level probably serves as a predictor of the development and severity of atherosclerosis on a cellular level. EPC, a relatively more important risk factor, perhaps protects against coronary artery disease.