EMAIL THIS PAGE TO A FRIEND

Genetics and molecular research : GMR

Association of the estrogen receptor-β gene RsaI and AluI polymorphisms with human idiopathic thin endometrium.


PMID 24338391

Abstract

The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-β gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (controls) were included in the study. RsaI and AluI polymorphisms of the ER-β gene were analyzed with polymerase chain reaction-restriction fragment length polymorphism. The distribution of polymorphisms, genotype, allele, and haplotype was compared between the 2 groups. A significant difference in the RsaI genotype was observed between idiopathic thin endometrium patients and controls. The distribution of the R allele of the RsaI polymorphism in idiopathic thin endometrium patients was 37.1% compared with 48.3% in controls. The odds ratio was 0.630 (95% confidence interval = 0.438 to 0.907, P = 0.013). No significant difference in the genotype of the AluI polymorphism was found between the two groups. The linkage disequilibrium between RsaI and AluI haploids was not significant in either group, with D' values of 0.2036 and 0.0685 in the idiopathic thin endometrium patients and controls, respectively. The results of this study suggest a potential role of the ER-β gene polymorphisms in the etiology of idiopathic atrophic endometrium and the R allele as a potential protective factor in ethnic Han Chinese.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

R6142 Acc I from Acinetobacter calcoaceticus, Restriction Enzyme
R8631
Bcl I from Bacillus caldolyticus, Restriction Enzyme
R3131
Bln I from Brevibacterium linens, buffered aqueous glycerol solution
R3635
Bsm I from Bacillus stearothermophilus NUB 36, Restriction Enzyme
R4253 BstE II from Bacillus stearothermophilus ET, Restriction Enzyme
R1761
Cfo I from Clostridium formicoaceticum, Restriction Enzyme
R7763
Cla I from Caryophanon latum L, Restriction Enzyme
R4256
Dde I from Desulfovibrio desulfuricans strain Norway, Restriction Enzyme
R4381
Dra I from Deinococcus radiophilus, Restriction Enzyme
R3884 EclX I from Enterobacter cloacae 590, Restriction Enzyme
R2756
EcoR V from Escherichia coli, buffered aqueous glycerol solution
R5628 Hae III from Haemophilus aegyptius, Restriction Enzyme
R1632
Mva I from Micrococcus varians Rfl 19, Restriction Enzyme
R8761 Nco I from Nocardia corallina, Restriction Enzyme
R5634
Nhe I from Neisseria mucosa heidelbergensis, Restriction Enzyme
R8506
Not I from Nocardia otidiscaviarum, Restriction Enzyme
R5884 Nsi I from Neisseria sicca, Restriction Enzyme
R1508
Pvu I from Proteus vulgaris, Restriction Enzyme
R2631
Pvu II from Proteus vulgaris, Restriction Enzyme
R4756 Rsa I from Rhodopseudomonas sphaeroides, Restriction Enzyme
R8256
Sfi I from Streptomyces fimbriatus, Restriction Enzyme
R7135 Sph I from Streptomyces phaeochromogenes, Restriction Enzyme
R1259 Afl III from Anabaena flos-aquae, buffered aqueous glycerol solution