EMAIL THIS PAGE TO A FRIEND

Proceedings of the National Academy of Sciences of the United States of America

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.


PMID 24344271

Abstract

Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models we demonstrate a role for interleukin (IL)-25 in the generation of pulmonary fibrosis. Mechanistically, we identify IL-13 release from type 2 innate lymphoid cells (ILC2) as sufficient to drive collagen deposition in the lungs of challenged mice and suggest this as a potential mechanism through which IL-25 is acting. Additionally, we demonstrate that in human idiopathic pulmonary fibrosis there is increased pulmonary expression of IL-25 and also observe a population ILC2 in the lungs of idiopathic pulmonary fibrosis patients. Collectively, we present an innate mechanism for the generation of pulmonary fibrosis, via IL-25 and ILC2, that occurs independently of T-cell-mediated antigen-specific immune responses. These results suggest the potential of therapeutically targeting IL-25 and ILC2 for the treatment of human fibrotic diseases.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

C9879 Collagen from bovine achilles tendon, powder, suitable for substrate for collagenase
C7806 Collagen from bovine nasal septum, Bornstein and Traub Type II, powder
C1188 Collagen from bovine tracheal cartilage, Bornstein and Traub Type II, powder
C8919 Collagen from calf skin, Bornstein and Traub Type I, (0.1% solution in 0.1 M acetic acid), aseptically processed, BioReagent, suitable for cell culture
C9791 Collagen from calf skin, Bornstein and Traub Type I, solid, BioReagent, suitable for cell culture
C9301 Collagen from chicken sternal cartilage, Type II (Miller), powder, BioReagent, suitable for cell culture
C0543 Collagen from Engelbreth-Holm-Swarm murine sarcoma basement membrane, Type IV (Miller), lyophilized powder (from 0.2 μm-filtered solution), BioReagent, suitable for cell culture
C7521
Collagen from human placenta, Bornstein and Traub Type IV, powder
C4407 Collagen from human placenta, Bornstein and Traub Type III (Sigma Type X), powder
C5533
Collagen from human placenta, Bornstein and Traub Type IV, powder, BioReagent, suitable for cell culture
C7774 Collagen from human placenta, Bornstein and Traub Type I (Sigma Type VIII), powder
C3657 Collagen from human placenta, Bornstein and Traub Type V (Sigma Type IX), powder
C8374
Collagen from human placenta, Bornstein and Traub Type IV, powder
H4417 Collagen from human placenta, Bornstein and Traub Type IV, solution, suitable for cell culture, ≥95% (SDS-PAGE)
C5608 Collagen from rabbit skin, Bornstein and Traub Type I, powder
C7661 Collagen from rat tail, Bornstein and Traub Type I, powder, BioReagent, suitable for cell culture
27666 Collagen from rat tail, for cell biology, soluble
C5483
Collagen human, Bornstein and Traub Type I, acid soluble, powder, ~95% (SDS-PAGE)
C7624
Collagen human, Bornstein and Traub Type I, recombinant, expressed in Nicotiana tabacum (tobacco)
C7999
Collagen human, Bornstein and Traub Type I, recombinant, expressed in Nicotiana tabacum (tobacco)
C8993 Collagen ovine, aqueous solution
C6745 Collagen Type IV from human cell culture, Bornstein and Traub Type IV, 0.3 mg/mL, sterile-filtered, BioReagent, suitable for cell culture
C3867 Collagen, Type I solution from rat tail, BioReagent, suitable for cell culture, sterile-filtered