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Advanced healthcare materials

High-density polymer microarrays: identifying synthetic polymers that control human embryonic stem cell growth.


PMID 24353271

Abstract

The fabrication of high-density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single-cellular-based screen. These high-density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up-scaling of the identified hit polymers enables long-term cellular cultivation and promoted successful stem-cell maintenance.