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Chemistry (Weinheim an der Bergstrasse, Germany)

Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.


PMID 24375713

Abstract

Hydrogen-bond mediated coupling of 1,2,3-triazoles to indoles and pyrroles results in N2 selective functionalization of the triazole moiety in moderate to excellent yields. The reaction was tolerant of un-, mono- and disubstituted triazoles and was applied to synthesize tryptophan derived fluorescent amino acids.

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131709
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