EMAIL THIS PAGE TO A FRIEND

Medical oncology (Northwood, London, England)

ALDH1 is a better clinical indicator for relapse of invasive ductal breast cancer than the CD44+/CD24- phenotype.


PMID 24519209

Abstract

Breast cancer stem cells are thought to be associated with metastasis and poor prognosis, but their clinical importance remains poorly understood. The aim of this study was to investigate whether certain phenotypes of breast cancer stem cells were clinically important factors regarding metastasis. Patients with primary breast cancer (n=121) were included in this study. Breast cancer stem cells were identified by immunohistochemical staining of CD44, CD24, and aldehyde dehydrogenase 1 (ALDH1) in tumor tissues from primary and recurrent or metastatic lesions. CD44+/CD24- cells and ALDH1+ cells were considered breast cancer stem cells. Sixty-five patients had metastatic or recurrent tumors. ALDH1+ tumors were significantly associated with a high rate of metastasis or recurrence (63.1%; P=0.026). Although there was no significant association between the proportion of CD44+/CD24- tumor cells and metastasis rates, a high proportion of CD44+/CD24- tumor cells was a risk factor for metastasis or recurrence (P=0.035). Changes in the proportion of CD44+/CD24- or ALDH1+ tumor cells between primary lesions and recurrent lesions were studied in 27 patients. The proportion of ALDH1+ tumor cells increased significantly (P=0.019) after recurrence, but the proportion of CD44+/CD24- tumor cells did not. Our findings suggest that ALDH1+ and CD44+/CD24- breast cancer stem cells play significant roles in metastasis. The rate of ALDH1+ cells appears to be a better predictive marker of breast cancer metastasis than the CD44+/CD24- phenotype.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB1405445
Anti-ALDH1A1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA002123
Anti-ALDH1A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2106201
Anti-ALDH1A1 antibody produced in rabbit, affinity isolated antibody, lyophilized powder
SAB2701626
Anti-aldh1a2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB2501484
Anti-ALDH2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
HPA051065
Anti-ALDH2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410363
Anti-ALDH2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
GW22755 Anti-CD44 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
SAB1405590
Anti-CD44 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA005785
Anti-CD44 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB4300691
Anti-CD44 antibody produced in rabbit, affinity isolated antibody
WH0000216M1
Monoclonal Anti-ALDH1A1 antibody produced in mouse, clone 1A2, purified immunoglobulin, buffered aqueous solution
SAB1403542
Monoclonal Anti-ALDH1A1 antibody produced in mouse, clone 1G6, purified immunoglobulin, buffered aqueous solution
SAB5300519 Monoclonal Anti-ALDH1A1 antibody produced in mouse, clone 5A11, ascites fluid
WH0000217M1
Monoclonal Anti-ALDH2 antibody produced in mouse, clone 1E5, purified immunoglobulin, buffered aqueous solution
SAB1408989
Monoclonal Anti-ALDH2 antibody produced in mouse, clone 4F10, purified immunoglobulin, buffered aqueous solution
SAB1408990
Monoclonal Anti-ALDH2 antibody produced in mouse, clone 4C11, purified immunoglobulin, buffered aqueous solution
SAB1402713
Monoclonal Anti-CD24 antibody produced in mouse, clone 1C4, purified immunoglobulin, buffered aqueous solution
SAB4700623 Monoclonal Anti-CD24 antibody produced in mouse, clone SN3, purified immunoglobulin, buffered aqueous solution
C7923 Monoclonal Anti-CD44 antibody produced in mouse, clone A3D8, purified immunoglobulin, buffered aqueous solution
SAB1402714
Monoclonal Anti-CD44 antibody produced in mouse, clone 1E1, purified immunoglobulin, buffered aqueous solution
SAB4700179 Monoclonal Anti-CD44 antibody produced in mouse, clone MEM-85, purified immunoglobulin, buffered aqueous solution
SAB4700184 Monoclonal Anti-CD44 antibody produced in mouse, clone MEM-263, purified immunoglobulin, buffered aqueous solution
SAB4700188 Monoclonal Anti-CD44 antibody produced in rat, clone IM7, purified immunoglobulin, buffered aqueous solution