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Chemical communications (Cambridge, England)

Proteome reactivity profiling for the discrimination of pathogenic bacteria.


PMID 24643251

Abstract

Diverse proteome reactivity profiles were obtained using small-molecule electrophiles. Based on the cross-reactivity profile, each protein generated a unique reactivity fingerprint. Here, we report the first proteome reactivity signature-based discrimination of 11 bacteria. Perfect differentiation of 11 bacteria can be achieved using 2 benzyl-halide probes.