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Journal of nanoscience and nanotechnology

Embedded carbon nanotubes nanoparticles in plasma membrane induce cellular calcium outflow imbalancing.


PMID 24738351

Abstract

In this report, embedded single-wall carbon nanotubes (SWCNTs) nanoparticles in plasma membrane inducing cellular calcium outflow imbalancing are disclosed. Compared ssDNA-SWCNTs with polystyrene (PS) nanoparticles, we analyzed the cytotoxicity of these nanoparticles and the effect of these nanoparticles on intracellular Ca2+ ion levels by depletion of Ca2+ from the endoplasmic reticulum (ER) evoked by Thapsigargin (Tg) in SKN-SH cells. The results had shown that ssDNA-SWCNTs and PS nanoparticles have no cytotoxicity on SKN-SH cells. However, contrary to PS nanoparticles, cellular Ca2+ ion outflow imbalancing was investigated in SKN-SH cells after pretreated with ssDNA-SWCNTs induced by Tg, which could be proposed mainly due to the interaction of embedded ssDNA-SWCNTs with cellular membrane.