EMAIL THIS PAGE TO A FRIEND

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo.


PMID 24923846

Abstract

Fisetin, an active compound isolated from flowering plants in the family Fabaceae, was reported to have antiviral, neuroprotective, and anti-inflammatory effects. Vascular inflammatory processes have been suggested to play key roles in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, we determined the ability of fisetin to suppress vascular inflammatory processes induced by high glucose (HG) in primary human umbilical vein endothelial cells (HUVECs) and mice. The effects of fisetin on HG-induced vascular inflammation were determined by measuring vascular permeability, leukocyte adhesion and migration, cell adhesion molecule (CAM) expression levels, reactive oxygen species (ROS) formation, and nuclear factor (NF)-κB activation. HG markedly increased vascular permeability, monocyte adhesion, expressions of CAMs, formation of ROS, and activation of NF-κB. Remarkably, all of the observed vascular inflammatory effects induced by HG were inhibited by pretreatment with fisetin. Vascular inflammatory responses induced by HG are critical events underlying the development of diabetic complications; therefore, our results suggest that fisetin possesses significant therapeutic effects against diabetic complications and atherosclerosis.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB4300383
Anti-ICAM1 (Ab-512) antibody produced in rabbit, affinity isolated antibody
SAB2502120
Anti-ICAM1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
SAB1405977
Anti-ICAM1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA002126
Anti-ICAM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
HPA004877
Anti-ICAM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1406579
Anti-VCAM1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
F4043
Fisetin, ≥98%
C15H10O6 · xH2O
SAB4700521 Monoclonal Anti-CD106 antibody produced in mouse, clone STA, purified immunoglobulin, buffered aqueous solution
SAB4700326 Monoclonal Anti-CD54 antibody produced in mouse, clone MEM-112, purified immunoglobulin, buffered aqueous solution
SAB4700571 Monoclonal Anti-CD54 antibody produced in rat, clone YN1/1.7.4, purified immunoglobulin, buffered aqueous solution
WH0003383M1
Monoclonal Anti-ICAM1 antibody produced in mouse, clone 3H8-2G6, purified immunoglobulin, buffered aqueous solution
V9263 Monoclonal Anti-Vascular Cell Adhesion Molecule 1 antibody produced in mouse, ~1 mg/mL, clone 1.4C3, purified immunoglobulin, buffered aqueous solution
SAB1402959
Monoclonal Anti-VCAM1 antibody produced in mouse, clone 1H6, purified immunoglobulin, buffered aqueous solution
SAB4100447
Monoclonal Anti-VCAM1 antibody produced in mouse, clone VCAM1-B382, culture supernatant
SAB1305743
ANTI-CD106 (CENTER) antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB1305520
MONOCLONAL ANTI-CD106 antibody produced in mouse, clone 582CT25.6.4, crude ascites, buffered aqueous solution
SAB4700327
Monoclonal Anti-CD54 antibody produced in mouse, clone MEM-111, purified immunoglobulin, buffered aqueous solution