EMAIL THIS PAGE TO A FRIEND

Clinical pharmacology and therapeutics

Warfarin pharmacogenetics: to genotype or not to genotype, that is the question.


PMID 24942399

Abstract

Genotype is well recognized to influence the dose of warfarin necessary for therapeutic anticoagulation. Recent randomized controlled trials evaluating the clinical utility of genotype-guided warfarin dosing have produced varying results. We review the design and results of the recent clinical trials, assess the impact of their findings on warfarin dosing, and examine unanswered questions related to clinical implementation of warfarin pharmacogenetics.