Veterinary anaesthesia and analgesia

Clinical comparison of two regimens of lidocaine infusion in horses undergoing laparotomy for colic.

PMID 24986751


To compare, in horses undergoing laparotomy for colic, the effects of administering or not administering a loading intravenous (IV) bolus of lidocaine prior to its constant rate infusion (CRI). Effects investigated during isoflurane anaesthesia were end-tidal isoflurane concentration (Fe'ISO), cardiovascular function, anaesthetic stability and the quality of recovery. Prospective, randomized clinical study. Thirty-six client-owned horses. Horses were assigned randomly to receive lidocaine as a CRI (50xa0μg kg(-1) xa0minute(-1) ) either preceded (LB) or not preceded (L) by a loading dose (1.5xa0mgxa0kg(-1) IV over 15xa0minutes). Lidocaine infusion (LInf) was started (T0) within 20xa0minutes after induction of general anaesthesia and discontinued approximately 30xa0minutes before the end of surgery. Anaesthetic depth, Fe'ISO, intra-operative physiological parameters and quality of recovery were assessed or measured. Data were analysed using one-way anova, t-test, Fisher test, Wilcoxon and Kruskal-Wallis tests as appropriate (pxa0