EMAIL THIS PAGE TO A FRIEND

American journal of clinical pathology

Reduced glucocorticoid receptor expression predicts bladder tumor recurrence and progression.


PMID 25015855

Abstract

To assess the levels of glucocorticoid receptor (GR) expression in bladder tumors because the status and its prognostic value remain largely unknown. We immunohistochemically stained for GR in bladder tumor and matched non-neoplastic bladder tissue specimens. Overall, GR was positive in 129 (87%) of 149 urothelial tumors, which was significantly (P=.026) lower than in non-neoplastic urothelium (90 [96%] of 94). Forty-two (79%) of 53 low-grade tumors vs 45 (47%) of 96 high-grade carcinomas (P<.001) and 61 (73%) of 84 non-muscle-invasive (NMI) tumors vs 26 (40%) of 65 muscle-invasive (MI) carcinomas (P<.001) were moderately to strongly immunoreactive for GR. Kaplan-Meier and log-rank tests revealed that loss or weak positivity of GR significantly or marginally correlated with recurrence of NMI tumors (P=.025), progression of MI tumors (P=.082), and cancer-specific survival of MI tumors (P=.067). Multivariate analysis identified low GR expression as a strong predictor for recurrence of NMI tumors (P=.034). GR expression was downregulated in bladder tumors compared with nonneoplastic bladder tumors and in high-grade/MI tumors compared with low-grade/NMI tumors. Decreased expression of GR, as an independent prognosticator, predicted recurrence of NMI tumors. These results support experimental evidence suggesting an inhibitory role of GR signals in bladder cancer outgrowth.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB2700744
Anti-GCGR (N-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
SAB4501309
Anti-GR antibody produced in rabbit, affinity isolated antibody
SAB4501310
Anti-GR antibody produced in rabbit, affinity isolated antibody
SAB4501311
Anti-GR antibody produced in rabbit, affinity isolated antibody
SAB1409153
Anti-GSR antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA001538
Anti-GSR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB1410585
Anti-GSR antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
HPA004248
Anti-NR3C1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2101649
Anti-NR3C1 antibody produced in rabbit, affinity isolated antibody
SAB1408583
Anti-NR3C1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution
SAB4800041
Imprint® Monoclonal Anti-GR antibody produced in mouse, purified antibody, buffered aqueous solution
SAB4200182
Monoclonal Anti-Glutathione Reductase antibody produced in mouse, ~1.0 mg/mL, clone GR6, purified immunoglobulin
WH0002936M1
Monoclonal Anti-GSR antibody produced in mouse, clone 6B4, purified immunoglobulin, buffered aqueous solution
WH0002908M1
Monoclonal Anti-NR3C1 antibody produced in mouse, clone 2C8, purified immunoglobulin, buffered aqueous solution
SAB5300231
Monoclonal Anti-NR3C1 antibody produced in mouse, clone 6E6, ascites fluid