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Cancer cell

Metabolic asymmetry in cancer: a "balancing act" that promotes tumor growth.


PMID 25026205

Abstract

Profound metabolic differences between cancer cells and fibroblasts promote tumorigenesis. A study by Valencia and colleagues in this issue of Cancer Cell supports this assertion. They observed that metabolic asymmetry in prostate tumors drives aggressive disease with high p62 in anabolic cancer cells, but loss of p62 in catabolic fibroblasts.