EMAIL THIS PAGE TO A FRIEND

Neurochemical research

Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury.


PMID 25107300

Abstract

Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to investigate the effects of saikosaponin a on neuropathic pain. Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve in rats. After CCI, rats were administered saikosaponin a (6.25, 12.50 and 25.00 mg/kg intraperitoneal, once daily) for 14 days. Mechanical withdrawal threshold and thermal withdrawal latency were assessed before surgery and on days 1, 3, 7, and 14 after CCI. Our results showed that CCI significantly decreased mechanical withdrawal threshold and thermal withdrawal latency on days 1, 3, 7 and 14, as compared with sham groups, however, saikosaponin a reversed this effects. In addition, saikosaponin a inhibited CCI-induced the levels of TNF-α, IL-1β, IL-2 in spinal cord. Western blot analysis demonstrated that saikosaponin a reduced the elevated expression of p-p38 mitogen-activated protein kinase (MAPK) and NF-κB in the spinal cord induced by CCI. These results suggest that saikosaponin a could effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

M7556 Anti-MAP Kinase 2 (ERK-2) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution, ~1 mg/mL
SAB4300499
Anti-MAPK14 (Ab-182) antibody produced in rabbit, affinity isolated antibody
SAB1405665
Anti-MAPK14 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
AV06004
Anti-MAPK14 antibody produced in rabbit, affinity isolated antibody
M0800
Anti-p38 MAP Kinase antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
SAB4500491
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody
SAB4500492
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody
SAB4500493
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody
SAB4300200
Anti-phospho-MAPK14 (pThr180) antibody produced in rabbit, affinity isolated antibody
SAB4300201
Anti-phospho-MAPK14 (pTyr182) antibody produced in rabbit, affinity isolated antibody
SAB4504095
Anti-phospho-p38 MAPK (pThr179+Tyr181) antibody produced in rabbit, affinity isolated antibody
SAB4504497
Anti-phospho-p38 MAPK (pThr180) antibody produced in rabbit, affinity isolated antibody
SAB4504498
Anti-phospho-p38 MAPK (pTyr182) antibody produced in rabbit, affinity isolated antibody
SAB4504094
Anti-phospho-p38 MAPK (pTyr322) antibody produced in rabbit, affinity isolated antibody
SAB4502906
Anti-Synaptophysin antibody produced in rabbit, affinity isolated antibody
SAB4200544
Anti-Synaptophysin antibody, Mouse monoclonal, clone SVP-38, purified from hybridoma cell culture
HPA002858
Anti-SYP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
SAB2102352
Anti-SYP antibody produced in rabbit, affinity isolated antibody
M7431 Monoclonal Anti-MAP Kinase 2 (ERK-2) antibody produced in mouse, clone 1B3B9, purified immunoglobulin, buffered aqueous solution
WH0006855M1
Monoclonal Anti-SYP antibody produced in mouse, clone 3B3, purified immunoglobulin, buffered aqueous solution