EMAIL THIS PAGE TO A FRIEND

International journal of oncology

Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo.


PMID 25201015

Abstract

FoxM1 is a specific transcription factor that has an important function in aggressive human carcinomas, including cervical cancer. However, the specific function and internal molecular mechanism in cervical cancer remain unclear. In this study, RNAi-mediated FoxM1 knockdown inhibited cell growth. This process also decreased the migration and invasion activities of HeLa cells in vitro. Downregulation of FoxM1 inhibited tumor growth and angiogenesis in vivo. In addition, the expressions of uPA, matrix metalloproteinase (MMP)-2, MMP-9 and VEGF were significantly decreased in vitro and in vivo. These results suggested that the inactivation of FoxM1 could be a novel therapeutic target for cervical cancer treatment.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

M4065 Anti-Matrix Metalloproteinase-2 antibody produced in rabbit, ~1 mg/mL, IgG fraction of antiserum, buffered aqueous solution
M9570 Anti-Matrix Metalloproteinase-9 antibody produced in goat, affinity isolated antibody
HPA001939
Anti-MMP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
AV20016
Anti-MMP2 antibody produced in rabbit, IgG fraction of antiserum
HPA001238
Anti-MMP9 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
AV33090
Anti-MMP9 antibody produced in rabbit, IgG fraction of antiserum
V6627 Anti-Vascular Endothelial Growth Factor antibody produced in goat, IgG fraction of antiserum, lyophilized powder
V1253 Anti-Vascular Endothelial Growth Factor antibody produced in goat, affinity isolated antibody, lyophilized powder
AMAB90805
Monoclonal Anti-MMP9 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0539, purified immunoglobulin, buffered aqueous glycerol solution
AMAB90804
Monoclonal Anti-MMP9 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0538, purified immunoglobulin, buffered aqueous glycerol solution
SAB5300247
Monoclonal Anti-MMP9 antibody produced in mouse, clone 5G3, ascites fluid
SAB5300248
Monoclonal Anti-MMP9 antibody produced in mouse, clone 5C3, ascites fluid
AMAB90806
Monoclonal Anti-MMP9 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0542, purified immunoglobulin, buffered aqueous glycerol solution
SAB1402274
Monoclonal Anti-MMP9 antibody produced in mouse, clone 2H4, purified immunoglobulin, buffered aqueous solution
V4758 Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse, clone 26503, purified immunoglobulin, lyophilized powder
SAB1402390
Monoclonal Anti-VEGF antibody produced in mouse, clone 3F7, purified immunoglobulin, buffered aqueous solution