EMAIL THIS PAGE TO A FRIEND

British journal of haematology

Aberrant expression of aldehyde dehydrogenase 1A (ALDH1A) subfamily genes in acute lymphoblastic leukaemia is a common feature of T-lineage tumours.


PMID 25208926

Abstract

The class 1A aldehyde dehydrogenase (ALDH1A) subfamily of genes encode enzymes that function at the apex of the retinoic acid (RA) signalling pathway. We detected aberrant expression of ALDH1A genes, particularly ALDH1A2, in a majority (72%) of primary paediatric T cell acute lymphoblastic leukaemia (T-ALL) specimens. ALDH1A expression was almost exclusive to T-lineage, but not B-lineage, ALL. To determine whether ALDH1A expression may have relevance to T-ALL cell growth and survival, the effect of inhibiting ALDH1A function was measured on a panel of human ALL cell lines. This revealed that T-ALL proliferation had a higher sensitivity to modulation of ALDH1A activity and RA signalling as compared to ALL cell lines of B-lineage. Consistent with these findings, the genes most highly correlated with ALDH1A2 expression were involved in cell proliferation and apoptosis. Evidence that such genes may be targets of regulation via RA signalling initiated by ALDH1A activity was provided by the TNFRSF10B gene, encoding the apoptotic death receptor TNFRSF10B (also termed TRAIL-R2), which negatively correlated with ALDH1A2 and showed elevated transcription following treatment of T-ALL cell lines with the ALDH1A inhibitor citral (3,7-dimethyl-2,6-octadienal). These data indicate that ALDH1A expression is a common event in T-ALL and supports a role for these enzymes in the pathobiology of this disease.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

242381
Benzoic acid, ACS reagent, ≥99.5%
C7H6O2
33045
Benzoic acid, for calorimetrical determination (approx. 26460 J/g)
C7H6O2
06185
Benzoic acid, Standard for quantitative NMR, TraceCERT®
C7H6O2
1055002
Benzoic acid, United States Pharmacopeia (USP) Reference Standard
C7H6O2
33047
Benzoic acid, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.9% (alkalimetric)
C7H6O2
18102
Benzoic acid, meets analytical specification of Ph. Eur., BP, USP, FCC, E210, 99.5-100.5% (alkalimetric)
C7H6O2
12356
Benzoic acid, tested according to Ph Eur
C7H6O2
PHR1050
Benzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material
C7H6O2
12353
Benzoic acid, certified reference material for titrimetry, certified by BAM, ≥99.5%
C7H6O2
47849
Benzoic acid, analytical standard
C7H6O2
427608
Benzoic acid, purified by sublimation, ≥99%
C7H6O2
109479
Benzoic acid, ReagentPlus®, 99%
C7H6O2
W213101
Benzoic acid, ≥99.5%, FCC, FG
C7H6O2
W213128
Benzoic acid, natural, ≥99.5%, FCC, FG
C7H6O2
Y0001470
Benzoic acid, European Pharmacopoeia (EP) Reference Standard
C7H6O2
W230316
Citral, natural, ≥96%, FCC, FG
C10H16O
C83007
Citral, 95%
C10H16O
43318
Citral, analytical standard
C10H16O
W230308
Citral, mixture of cis and trans, ≥96%, FG
C10H16O
76170
Melting point standard 121-123°C, analytical standard
C7H6O2
73983
Mettler-Toledo Calibration substance ME 18555, Benzoic acid, analytical standard, for the calibration of the thermosystem 900, traceable to primary standards (LGC)
C7H6O2
8S61336
SS Benzoic Acid, 2000 μg/mL in dichloromethane, analytical standard
C7H6O2