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Journal of veterinary pharmacology and therapeutics

The effect of sucralfate tablets vs. suspension on oral doxycycline absorption in dogs.


PMID 25233871

Abstract

The purpose of this study was to determine the effect of concurrent sucralfate (tablet or suspension) on doxycycline pharmacokinetics and to determine the effects of delaying sucralfate by 2xa0h on doxycycline absorption. Five dogs were included in a crossover study receiving: doxycycline alone; doxycycline concurrently with sucralfate tablet; doxycycline followed 2xa0h by sucralfate tablet; doxycycline concurrently with sucralfate suspension; and doxycycline followed 2xa0h by sucralfate suspension. Doxycycline plasma concentrations were evaluated with liquid chromatography with mass spectrometry. No interaction was seen when sucralfate was administered as a tablet. Sucralfate tablet fragments were frequently observed in some dogs' feces. The area under the curve (AUC) and maximum plasma concentration (CMAX ) were significantly lower (Pxa0

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