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Clinica chimica acta; international journal of clinical chemistry

Shift of the interconnection from the reaction system of paraoxonase 1 to the peroxidation reaction system of myeloperoxidase with HDL-C levels: a marker of atherosclerosis in patients with normal cholesterol levels.


PMID 25269090

Abstract

The interconnectivity of the peroxidation reaction system of myeloperoxidase (PRSM) or the reaction system of paraoxonase 1 (RSP1) with atherosclerosis remains elusive in patients with normal cholesterol levels. A total of 55 atherosclerotic patients with normal cholesterol concentrations and 45 control subjects were analyzed. Pearson's correlation was used to investigate the correlation between the levels of oxidative stress-related indices (HNE-LDL, MDA-LDL and protein carbonyls) and cholesterol indices (TC, HDL-C and LDL-C) and individual factor in RSP1 and PRSM (paraoxonase 1 activity, ionized calcium, myeloperoxidase peroxidation activity, or H2O2). Response surface regression (RSR) was used to analyze the interconnection of PRSM and RSP1 with the levels of oxidative stress-related indices and cholesterol indices. The relation between PRSM and the increase of HNE-LDL and MDA-LDL was attributable to myeloperoxidase peroxidation activity, H2O2 concentrations and the interaction between myeloperoxidase peroxidation activity and H2O2 in the patients. PRSM preferred contribution to cholesterol levels in the cases. The interconnection of PRSM with TC was dependent on the association of PRSM with HDL-C and LDL-C. The shift of interconnection with HDL-C levels from RSP1 to PRSM represents a marker for atherosclerotic patients with normal cholesterol levels.