EMAIL THIS PAGE TO A FRIEND

Eksperimentalna meditsina i morfologiia

[Study of the effect of analgeton on the release of beta-endorphin and its effect on chronic hyperalgesia].


PMID 2530083

Abstract

The effect of the combined preparation analgeton and its components--analgin (metamizol, noramidopyrindimethansulfonate) and aminton (2-amino-4-methyl-pyridinphosphate) was studied on the release of beta-endorphin and its influence on chronic hyperalgesia. Experiments were carried out in vivo and in vitro on white rats and it was established that analgin, aminton and analgeton stimulated the release of beta-endorphin, affecting various regulatory levels. Analgeton in contrast to analgin showed longer analgetic effect in animals with chronic hyperalgesia (adjuvant arthritis of white rats). Possibilities for pharmacological control of chronic pain by influencing the levels of endogenous opioids are discussed.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

123080
2-Amino-4-methylpyridine, 99%
C6H8N2