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Organic letters

Phenazinium salt-catalyzed aerobic oxidative amidation of aromatic aldehydes.


PMID 25350690

Abstract

Amides are prevalent in organic synthesis. Developing an efficient synthesis that avoids expensive oxidants and heating is highly desirable. Here the oxidative amidation of aromatic aldehydes is reported using an inexpensive metal-free visible light photocatalyst, phenazine ethosulfate, at low catalytic loading (1-2 mol %). The reaction proceeds at ambient temperature and uses air as the sole oxidant. The operationally easy procedure provides an economical, green, and mild alternative for the formation of amide bonds.

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P4544
Phenazine ethosulfate, ≥95%
C16H18N2O4S