EMAIL THIS PAGE TO A FRIEND

Nature communications

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells.


PMID 25355530

Abstract

Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here that the protein tyrosine phosphatase SHP-1 is essential for the inhibitory function of NK cell MHC class I receptors. In the absence of SHP-1, NK cells are hyporesponsive to tumour cells in vitro and their early Ca(2+) signals are compromised. Mice without SHP-1 in NK cells are unable to reject MHC class I-deficient transplants and to control tumours in vivo. Thus, the inhibitory activity of SHP-1 is needed for setting the threshold of NK cell reactivity.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

SAB2101628
Anti-NR0B2 (ab1) antibody produced in rabbit, affinity isolated antibody
SAB2101629
Anti-NR0B2 (ab2) antibody produced in rabbit, affinity isolated antibody
SAB2101630
Anti-NR0B2 (ab3) antibody produced in rabbit, affinity isolated antibody
SAB2101631
Anti-NR0B2 (ab4) antibody produced in rabbit, affinity isolated antibody
SAB1406664
Anti-NR0B2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB4300558
Anti-PTPN6 (Ab-536) antibody produced in rabbit, affinity isolated antibody
SAB1406344
Anti-PTPN6 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
HPA001466
Anti-PTPN6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
GW21487 Anti-PTPNS1 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution
SAB1408349
Anti-SIRPA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution
SAB2102154
Anti-SIRPA antibody produced in rabbit, affinity isolated antibody
27066
Chromium, coating quality, 99.95%, grit
Cr
374849
Chromium, chips, 99.995% trace metals basis
Cr
255610
Chromium, chips, thickness ~2 mm, 99.5%
Cr
229563
Chromium, chunks, ≥99.99% trace metals basis
Cr
266264
Chromium, powder, 99.5%, −100 mesh
Cr
266299
Chromium, powder, ≥99% trace metals basis, −325 mesh
Cr
749052
Chromium, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.95% trace metals basis
Cr
GF97385338
Chromium, foil, not light tested, 100x100mm, thickness 0.02mm, permanent polyester support, 99.99+%
Cr
GF23770885
Chromium, foil, not light tested, 100x100mm, thickness 0.03mm, permanent polyester support, 99.99+%
Cr
GF24605816
Chromium, foil, not light tested, 100x100mm, thickness 0.04mm, permanent polyester support, 99.99+%
Cr
GF22618739
Chromium, foil, not light tested, 100x100mm, thickness 0.05mm, permanent polyester support, 99.99+%
Cr
GF00270593
Chromium, foil, not light tested, 25x25mm, thickness 0.0015mm, permanent polyester support, 99.99+%
Cr
GF88955410
Chromium, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 99.99+%
Cr
GF94865170
Chromium, foil, not light tested, 25x25mm, thickness 0.0025mm, permanent polyester support, 99.99+%
Cr
GF73692377
Chromium, foil, not light tested, 25x25mm, thickness 0.002mm, permanent polyester support, 99.99+%
Cr
GF61658725
Chromium, foil, not light tested, 25x25mm, thickness 0.003mm, permanent polyester support, 99.99+%
Cr
GF81124286
Chromium, foil, not light tested, 25x25mm, thickness 0.004mm, permanent polyester support, 99.99+%
Cr
GF05241316
Chromium, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 99.99+%
Cr
GF98123250
Chromium, foil, not light tested, 25x25mm, thickness 0.006mm, permanent polyester support, 99.99+%
Cr