EMAIL THIS PAGE TO A FRIEND

Molecules (Basel, Switzerland)

Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening.


PMID 25415480

Abstract

We describe a ligand-based approach towards compounds with more specific targeting for Burkitt's lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically different but with similar spatial conformations. Biological evaluation revealed that one compound has better growth inhibition and improved selectivity towards Burkitt's lymphoma cells than the query compound. However, initial mechanism-of-action studies show a different target profile in comparison with the previous hit compound, which does not involve the inhibition of the proteasome or the NFκB pathway. The data from this study provide a solid basis for further efforts in the search for selective agents against Burkitt's lymphoma.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

A0466
N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin, ≥90% (HPLC), powder
C30H34F3N5O13