EMAIL THIS PAGE TO A FRIEND

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes.


PMID 25460149

Abstract

A spatial filtering velocimetry (SFV) probe was applied to monitor the increase in particle size during pellet Wurster coating processes in-line. Accuracy of the in-line obtained pellet sizes was proven by at-line performed digital image analysis (DIA). Regarding particle growth, high conformity between both analytical methods (SFV/DIA) was examined for different coating processes. The influence of ring buffer size and the process of filling the buffer were investigated. With buffer sizes of 30,000-50,000 particles best results were obtained in this study. Investigated process parameters, such as inlet air volume and spray rate, had different effects on the impact of the SFV probe. While the particle rate (the number of particles detected by the SVF probe per second) was highly dependent on the inlet air volume, different spray rates of up to ・}1 g/min did not affect the detected particle growth. Artefacts and delays in SFV particle sizing appeared especially at the beginning of the coating processes. The slope of the particle growth during the final spraying period was therefore used to determine coating thickness.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

M2015
1-Stearoyl-rac-glycerol, ≥99%
C21H42O4
77402
Melting Point Standard 69-71°C, analytical standard
C18H36O2
76137
Stearic acid, certified reference material, TraceCERT®
C18H36O2
85679
Stearic acid, analytical standard
C18H36O2
85680
Stearic acid, puriss., ≥98.5% (GC)
C18H36O2
1621008
Stearic acid, United States Pharmacopeia (USP) Reference Standard
C18H36O2
S1340000
Stearic acid, European Pharmacopoeia (EP) Reference Standard
C18H36O2
PHR1114
Stearic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
C18H36O2
677469
Titanium(IV) oxide, contains 1% Mn as dopant, nanopowder, <100 nm particle size (BET), ≥97%
O2Ti
718467
Titanium(IV) oxide, nanopowder, 21 nm primary particle size (TEM), ≥99.5% trace metals basis
O2Ti
774510
Titanium(IV) oxide, nanowires, diam. × L ~100 nm × 10 μm
O2Ti
774529
Titanium(IV) oxide, nanowires, diam. × L ~10 nm × 10 μm
O2Ti
637254
Titanium(IV) oxide, anatase, nanopowder, <25 nm particle size, 99.7% trace metals basis
O2Ti
232033
Titanium(IV) oxide, anatase, powder, 99.8% trace metals basis
O2Ti
248576
Titanium(IV) oxide, anatase, powder, −325 mesh, ≥99% trace metals basis
O2Ti
634662
Titanium(IV) oxide, mixture of rutile and anatase, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis
O2Ti
700355
Titanium(IV) oxide, mixture of rutile and anatase, nanoparticle, <250 nm particle size (DLS), paste, 53-57 wt. % in diethylene glycol monobutyl ether/ethylene glycol, 99.9% trace metals basis
O2Ti
700347
Titanium(IV) oxide, mixture of rutile and anatase, nanoparticles, <150 nm particle size (volume distribution, DLS), dispersion, 33-37 wt. % in H2O, 99.5% trace metals basis
O2Ti
700339
Titanium(IV) oxide, mixture of rutile and anatase, nanoparticles, <100 nm particle size, dispersion, 48-52 wt. % in xylene, 99.9% trace metals basis
O2Ti
204730
Titanium(IV) oxide, rutile, 99.995% trace metals basis
O2Ti
204757
Titanium(IV) oxide, rutile, ≥99.98% trace metals basis
O2Ti
635057
Titanium(IV) oxide, rutile, <001>, (single crystal substrate), 99.99% trace metals basis, L × W × thickness 10 mm × 10 mm × 0.5 mm
O2Ti
635049
Titanium(IV) oxide, rutile, <100>, (single crystal substrate), 99.99% trace metals basis, L × W × thickness 10 mm × 10 mm × 0.5 mm
O2Ti
635065
Titanium(IV) oxide, rutile, <110>, single crystal substrate, 99.99% trace metals basis, L × W × thickness 10 mm × 10 mm × 0.5 mm
O2Ti
637262
Titanium(IV) oxide, rutile, nanopowder, <100 nm particle size, 99.5% trace metals basis
O2Ti
224227
Titanium(IV) oxide, rutile, powder, <5 μm, ≥99.9% trace metals basis
O2Ti
14849
Triethyl citrate, analytical standard
C12H20O7
27500
Triethyl citrate, ≥98.0% (GC)
C12H20O7
W308307
Triethyl citrate, ≥99%, FCC, FG
C12H20O7
W308315
Triethyl citrate, natural, ≥97%, FG
C12H20O7