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Organic letters

Enantioselective construction of functionalized thiopyrano-indole annulated heterocycles via a formal thio [3 + 3]-cyclization.


PMID 25517293

Abstract

A formal thio [3 + 3]-cyclization catalyzed by a DPEN-derived chiral thiourea has been reported for the construction of optically active thiopyrano-indole annulated heterocyclic compounds in high yields with excellent enantioselectivities. The high reactivity between indoline-2-thione (keto-S) and 2-benzylidenemalononitrile has also been supported by density functional theory (DFT) calculations.