EMAIL THIS PAGE TO A FRIEND

Bioorganic & medicinal chemistry letters

Synthesis, antimycobacterial and antifungal evaluation of some new 1-ethyl-5-(hetero)aryl-6-styryl-1,6-dihydropyrazine-2,3-dicarbonitriles.


PMID 25556103

Abstract

The Petasis reaction of 6-hydroxy adducts of 1-alkyl-2,3-dicyano-5-arylpyrazinium salts with trans-styrylboronic acids proved to proceed smoothly at room temperature to give the corresponding 5-(hetero)aryl-6-styryl substituted 1,6-dihydropyrazine derivatives. Also it has been found that C(6) unsubstituted 1,6-dihydro- or 1,4,5,6-tetrahydropyrazine derivatives can be easy prepared in high yields from the corresponding pyrazinium salts by reduction with triethylsilane. All synthesized compounds were screened in vitro for their antifungal activities against seven pathogenic fungal strains and antimycobacterial activities against Mycobacterium tuberculosis H37Rv, avium, terrae and multi-drug-resistant strains isolated from tuberculosis patients in the Ural region (Russia).

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

K08971227 Kromasil® CelluCoat® Chiral HPLC Column, 3 μm particle size, L × I.D. 50 mm × 2.1 mm
K08971223 Kromasil® CelluCoat® Chiral HPLC Column, 3 μm particle size, L × I.D. 150 mm × 2.1 mm
K08971228 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 50 mm × 2.1 mm
K08971224 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 150 mm × 2.1 mm
K08670372 Kromasil® CelluCoat® Chiral HPLC Column, 3 μm particle size, L × I.D. 50 mm × 4.6 mm
K08670370 Kromasil® CelluCoat® Chiral HPLC Column, 3 μm particle size, L × I.D. 150 mm × 4.6 mm
K08670617 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 50 mm × 4.6 mm
K08670373 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 150 mm × 4.6 mm
K08670374 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 250 mm × 4.6 mm
K08670614 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 250 mm × 10 mm
K08670615 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 250 mm × 21.2 mm
K08670616 Kromasil® CelluCoat® Chiral HPLC Column, 5 μm particle size, L × I.D. 250 mm × 30 mm
K08670612 Kromasil® CelluCoat® Chiral HPLC Column, 10 μm particle size, L × I.D. 150 mm × 4.6 mm
K08670613 Kromasil® CelluCoat® Chiral HPLC Column, 10 μm particle size, L × I.D. 250 mm × 4.6 mm
K08670609 Kromasil® CelluCoat® Chiral HPLC Column, 10 μm particle size, L × I.D. 250 mm × 10 mm
K08670610 Kromasil® CelluCoat® Chiral HPLC Column, 10 μm particle size, L × I.D. 250 mm × 21.2 mm
K08670611 Kromasil® CelluCoat® Chiral HPLC Column, 10 μm particle size, L × I.D. 250 mm × 30 mm
K08670502 Kromasil® CelluCoat® Chiral Reversed Phase HPLC Column, 3 μm particle size, L × I.D. 50 mm × 4.6 mm
K08670503 Kromasil® CelluCoat® Chiral Reversed Phase HPLC Column, 3 μm particle size, L × I.D. 150 mm × 4.6 mm