Palmolein and olive oil consumed within a high protein test meal have similar effects on postprandial endothelial function in overweight and obese men: A randomized controlled trial.

PMID 25617858


This study assessed the postprandial effects of high fat, high protein meals containing either palmolein or olive oil on endothelial function in overweight/obese men. 28 men (32-65xa0yr; 25-35xa0kg/m(2)) consumed, in random order 1xa0wk apart, isocaloric high protein, high fat meals (2791xa0kJ, 40xa0g protein (∼3xa0g l-arginine), 44xa0g fat, 21xa0g carbohydrate) prepared with either 40xa0g palmolein or 40xa0g olive oil after an overnight fast. The SFA:MUFA:PUFA ratio of the oils were: palmolein, 42:47:12; olive oil, 17:76:7. Brachial artery flow-mediated dilatation (FMD), circulating endothelial function markers, nitrotyrosine (oxidative stress marker), triglycerides, glucose and insulin were assessed pre-meal and hourly for 5xa0h. Mixed model procedures were used to analyze the data. Meal consumption increased serum triglycerides (time effect, Pxa0xa00.4). Olive oil transiently increased plasma nitrotyrosine after 1xa0h compared to palmolein (mealxa0×xa0time interaction, Pxa0=xa00.002) whereas both meals increased serum vascular cell adhesion molecule-1 (VCAM-1) after 1xa0h (time effect, Pxa0