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Cornea

Topically administered gold nanoparticles inhibit experimental corneal neovascularization in mice.


PMID 25625363

Abstract

The aim of this study was to evaluate the in vivo effects and mechanism of topically administered gold nanoparticles (AuNP) in a mouse model of corneal neovascularization. Inflammatory corneal neovascularization was induced by alkali burns, and the corneas were treated with topical AuNPs. After 1 week, the area of corneal neovascularization was measured using image analysis. The levels of vascular endothelial growth factor receptor 2 and extracellular signal-regulated kinase (ERK1/2) were evaluated by Western blotting. The area of corneal neovascularization was significantly reduced by 39.8% in the AuNP group compared with the control group (P = 0.002). Corneal vascular endothelial growth factor receptor 2 level was higher in the control group than in the AuNP-treated group (P = 0.029). AuNP treatment similarly inhibited burn-induced phosphorylation of ERK (P = 0.029). Topical administration of AuNPs significantly reduced development of inflammatory corneal neovascularization by inhibiting the ERK pathway.