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Asian Pacific journal of cancer prevention : APJCP

Expression of IER3 in primary hepatocarcinoma: correlation with clinicopathological parameters.


PMID 25684507

Abstract

Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.

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