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Pharmacotherapy

Effectiveness of regular versus glargine insulin in stable critical care patients receiving parenteral nutrition: a randomized controlled trial.


PMID 25689245

Abstract

To compare the effectiveness and safety of two glycemic control regimens in stable critical care patients receiving parenteral nutrition (PN). Prospective, randomized open-label clinical trial. Eligible postoperative critical care patients in the ICU began PN on the first to the seventh day of ICU admission. The PN admixture included regular insulin, in doses sufficient to maintain 3 or more goal blood glucose (BG) levels between 110 and 180xa0mg/dl. After 3 to 5xa0days of PN containing regular insulin, patients were randomized to 3 more days of regular insulin at the same dose or 80% of their total daily regular insulin dose provided in PN solution as glargine insulin. Capillary BG monitoring was performed every 6xa0hours. Twenty one patients were randomized to each treatment group. Median APACHE II scores were not significantly different between the two groups within the first 24-hour of ICU admission. There were no significant differences between the two groups at day 3 for mean daily dextrose (306.9xa0±xa046.2 vs. 305.2xa0±xa052.2xa0g; p=0.913) or insulin (18.3xa0±xa08.8 vs. 19.5xa0±xa010.0xa0units; p=0.696) doses. The percentage of BG values in the goal (110-180xa0mg/dl), hyperglycemic (>xa0180xa0mg/dl), and hypoglycemic (