EMAIL THIS PAGE TO A FRIEND

The European journal of neuroscience

High-frequency stimulation of the medial prefrontal cortex decreases cellular firing in the dorsal raphe.


PMID 25712703

Abstract

High-frequency deep brain stimulation (HFS-DBS) of the subcallosal cingulate (SCC) region has been investigated as a treatment for refractory forms of depression with a ~50% remission rate in open label studies. However, the therapeutic mechanisms of DBS are still largely unknown. Using anaesthetized Sprague Dawley rats, we recorded neuronal spiking activity in 102 neurons of the dorsal raphe (DR) before, during and after the induction of a 5-min HFS train in the infralimbic region (IL) of the medial prefrontal cortex (mPFC), the rodent homologue of the human SCC. The majority of DR cells (82%) significantly decreased firing rate during HFS (Pxa0

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

14340
(+)-Bicuculline, ≥97.0% (TLC)
C20H17NO6
U2500
Urethane, ≥99%
C3H7NO2
94300
Urethane, ≥99.0% (GC)
C3H7NO2