EMAIL THIS PAGE TO A FRIEND

PloS one

Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity.


PMID 25760987

Abstract

Despite the ever-increasing number of patients with dementia worldwide, fundamental therapeutic approaches to this condition have not been established. Epidemiological studies suggest that intake of fermented dairy products prevents cognitive decline in the elderly. However, the active compounds responsible for the effect remain to be elucidated. The present study aims to elucidate the preventive effects of dairy products on Alzheimer's disease and to identify the responsible component. Here, in a mouse model of Alzheimer's disease (5xFAD), intake of a dairy product fermented with Penicillium candidum had preventive effects on the disease by reducing the accumulation of amyloid β (Aβ) and hippocampal inflammation (TNF-α and MIP-1α production), and enhancing hippocampal neurotrophic factors (BDNF and GDNF). A search for preventive substances in the fermented dairy product identified oleamide as a novel dual-active component that enhanced microglial Aβ phagocytosis and anti-inflammatory activity towards LPS stimulation in vitro and in vivo. During the fermentation, oleamide was synthesized from oleic acid, which is an abundant component of general dairy products owing to lipase enzymatic amidation. The present study has demonstrated the preventive effect of dairy products on Alzheimer's disease, which was previously reported only epidemiologically. Moreover, oleamide has been identified as an active component of dairy products that is considered to reduce Aβ accumulation via enhanced microglial phagocytosis, and to suppress microglial inflammation after Aβ deposition. Because fermented dairy products such as camembert cheese are easy to ingest safely as a daily meal, their consumption might represent a preventive strategy for dementia.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

52750
Hexane, analytical standard
C6H14
L1376
Linoleic acid, ≥99%
C18H32O2
L1012
Linoleic acid, liquid, BioReagent, suitable for cell culture
C18H32O2
62230
Linoleic acid, analytical standard
C18H32O2
62240
Linoleic acid, technical, 58-74% (GC)
C18H32O2
L2376
Linolenic acid, ≥99%
C18H30O2
62170
Linolenic acid, ~70% (GC)
C18H30O2
62160
Linolenic acid, analytical standard
C18H30O2
L7895 Lipopolysaccharides from Salmonella typhosa, γ-irradiated, BioXtra, suitable for cell culture
77402
Melting Point Standard 69-71°C, analytical standard
C18H36O2
08393
Oleamide, analytical standard
C18H35NO
O2136
Oleamide, ≥99%
C18H35NO
75090
Oleic acid, analytical standard
C18H34O2
Y0001479
Oleic acid, European Pharmacopoeia (EP) Reference Standard
C18H34O2
05508
Oleic acid, Selectophore, ≥99.0%
C18H34O2
O0140000
Plastic additive 20, European Pharmacopoeia (EP) Reference Standard
C18H35NO
81377
Poly(tetrafluoroethylene), beads
]n
430935
Poly(tetrafluoroethylene), powder (free-flowing), 1 μm particle size
]n
430943
Poly(tetrafluoroethylene), powder (free-flowing), ≤12 μm particle size
]n
468096
Poly(tetrafluoroethylene), powder, 35 μm particle size
]n
182478
Poly(tetrafluoroethylene), powder, >40 μm particle size
]n
737992
Poly(tetrafluoroethylene), powder, 200 μm particle size
]n
738670
Poly(tetrafluoroethylene), powder, ≥350 μm particle size
]n
S4751
Stearic acid, Grade I, ≥98.5% (capillary GC)
C18H36O2
76137
Stearic acid, certified reference material, TraceCERT®
C18H36O2
85679
Stearic acid, analytical standard
C18H36O2
W303518
Stearic acid, ≥95%, FCC, FG
C18H36O2
175366
Stearic acid, reagent grade, 95%
C18H36O2
1621008
Stearic acid, United States Pharmacopeia (USP) Reference Standard
C18H36O2
S1340000
Stearic acid, European Pharmacopoeia (EP) Reference Standard
C18H36O2