EMAIL THIS PAGE TO A FRIEND

Dermatology (Basel, Switzerland)

L-Tryptophan as a Novel Potential Pharmacological Treatment for Wound Healing via Aryl Hydrocarbon Receptor Activation.


PMID 25765536

Abstract

The aryl hydrocarbon receptor has been shown to be involved in wound healing. The aim of this study was to assess the effect of tryptophan on wound healing in vitro and in a clinical trial. The ability of tryptophan and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to increase wound healing was assessed in an in vitro scratch wound model in human keratinocytes. Topical tryptophan and vehicle were assessed for 12 weeks in 51 patients with lower limb ulcers that were resistant to conventional therapies. TCDD 0.1 nM and tryptophan 1 µM increased the rate of scratch recovery in a culture model. Topical tryptophan induced stronger pain relief and faster re-epithelialization than its vehicle in patients with lower limb ulcers. Tryptophan shows promising potential as a novel topical treatment for wound healing.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

424455
Resorufin, Dye content 95 %
C12H7NO3
73144
Resorufin, 95%
C12H7NO3