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Journal of pharmaceutical and biomedical analysis

Characterization of the impurities and isomers in cefetamet pivoxil hydrochloride by liquid chromatography/time-of-flight mass spectrometry and ion trap mass spectrometry.


PMID 25863019

Abstract

Ten impurities and isomers in cefetamet pivoxil hydrochloride drug substance made in China were separated and identified by HPLC-MS(n) (TOF and TRAP). Their fragmentation patterns and structural assignment were studied based on the HPLC-MS(n) data. Among the ten impurities and isomers, impurity VII was isolated by preparative HPLC, and its structure was confirmed by (1)H NMR data.