Fractal dimension: a novel clot microstructure biomarker use in ST elevation myocardial infarction patients.

PMID 25890059


Changes in clot microstructure are increasingly implicated in the pathology of atherosclerosis although most data are from techniques in the remote laboratory using altered blood. We validate the novel biomarker Gel Point in STEMI patients and assess therapeutic interventions. Gel Point marks the transition of blood from a visco-elastic liquid to visco-elastic solid and is rapidly measured using unadulterated blood. The Gel Point provides measurements of three parameters to reflect clot microstructure (fractal dimension (df)), real-time clot formation time (TGP) and blood clot strength (elasticity at the Gel Point (G'GP)). We prospectively recruited 38 consecutive patients with STEMI undergoing primary percutaneous coronary intervention (pPCI). Venous blood samples were collected on admission, after pPCI and 24xa0h after admission for assessment of the new biomarkers, standard coagulation tests and scanning electron microscopy (SEM). df after pPCI was lower than df on admission (mean 1.631 [SD 0.063] vs 1.751 [0.052], pxa0