EMAIL THIS PAGE TO A FRIEND

Oncoimmunology

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.


PMID 25941590

Abstract

In many cancers, regulatory T cells (Treg) play a crucial role in suppressing the effector immune response thereby permitting tumor development. Indeed, in mouse models, their depletion can promote the regression of tumors of various origins, including renal cell carcinoma when located subcutaneous (SC). In the present study, we aimed to assess the importance of Treg immunosuppression in the physiologic context of metastatic renal carcinoma (Renca) disease. To that purpose we inoculated renal tumors orthotopically, intra-kidney (IK), in mice. Treg depletions were performed using anti-CD4 antibody in wild type mice or diphtheria toxin (DT) in

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

D1602
1-Decanethiol, 96%
C10H22S
705233
1-Decanethiol, 99%
C10H22S