EMAIL THIS PAGE TO A FRIEND

Journal of enzyme inhibition and medicinal chemistry

Studies of C-terminal naphthoquinone dipeptides as 20S proteasome inhibitors.


PMID 25942361

Abstract

The ubiquitin proteasome pathway is crucial in regulating many processes in the cell. Modulation of proteasome activities has emerged as a powerful strategy for potential therapies against much important pathologies. In particular, specific inhibitors may represent a useful tool for the treatment of tumors. Here, we report studies of a new series of peptide-based analogues bearing a naphthoquinone pharmacophoric unit at the C-terminal position. Some derivatives showed inhibition in the µM range of the post-acidic-like and chymotrypsin-like active sites of the proteasome.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

C0483
Z-Leu-Leu-Glu-7-amido-4-methylcoumarin, ≥95%, solid
C35H44N4O9