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Microbial pathogenesis

Assessment of adhesion, invasion and cytotoxicity potential of oral Staphylococcus aureus strains.


PMID 26055540

Abstract

The oral cavity is regarded as a relevant site for Staphylococcus aureus colonization. However, characterization of virulence mechanisms of oral S.xa0aureus remains to be uncovered. In this study, twenty one S.xa0aureus strains isolated from the oral cavity of Tunisian patients were screened for adherence, invasion and cytotoxicity against HeLa cells. In addition, the presence of adhesins (icaA, icaD, can, fnbA and fnbB) and α-hemolysin (hla) genes in each strain was achieved by polymerase chain reaction (PCR). Our finding revealed that oral S.xa0aureus strains were able to adhere and invade epithelial cells, with variable degrees (Pxa0