EMAIL THIS PAGE TO A FRIEND

Advanced functional materials

Injectable Peptide Decorated Functional Nanofibrous Hollow Microspheres to Direct Stem Cell Differentiation and Tissue Regeneration.


PMID 26069467

Abstract

Injectable microspheres are attractive stem cell carriers for minimally invasive procedures. For tissue regeneration, the microspheres need to present the critical cues to properly direct stem cell differentiation. In natural extracellular matrix (ECM), growth factors (GFs) and collagen nanofibers provide critical chemical and physical cues. However, there have been no reported technologies that integrate synthetic nanofibers and GFs into injectable microspheres. In this study, we synthesized functional nanofibrous hollow microspheres (FNF-HMS), which can covalently bind GF-mimicking peptides. Two different GF-mimicking peptides, Transforming Growth Factor-β1 mimicking peptide Cytomodulin (CM) and Bone Morphogenetic Protein-2 mimicking peptide P24, were separately conjugated onto the FNF-HMS to induce distinct differentiation pathways of rabbit bone marrow-derived mesenchymal stem cells (BMSCs). While no existing biomaterials were reported to successfully deliver CM to induce chondrogenesis, the developed FNF-HMS were shown to effectively present CM to BMSCs and successfully induced their chondrogenesis for cartilage formation in both

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

367044
(3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione, 98%
C6H8O4
34857
1,4-Dioxane, for HPLC, ≥99.5%
C4H8O2
296309
1,4-Dioxane, anhydrous, 99.8%
C4H8O2
360481
1,4-Dioxane, ACS reagent, ≥99.0%
C4H8O2
676934
1,4-Dioxane, ACS reagent, ≥99.0%
C4H8O2
33147
1,4-Dioxane, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)
C4H8O2
76887
1,4-Dioxane, analytical standard
C4H8O2
D201863
1,4-Dioxane, ReagentPlus®, ≥99%
C4H8O2
PHR1549
1,4-Dioxane, Pharmaceutical Secondary Standard; Certified Reference Material
C4H8O2
441090
2,2′-Azobis(2-methylpropionitrile), 98%
C8H12N4
755745
2,2′-Azobis(2-methylpropionitrile), recrystallized, 99%
C8H12N4
17348
2-Hydroxyethyl methacrylate, embedding medium (for microscopy)
C6H10O3
477028
2-Hydroxyethyl methacrylate, ≥99%, contains ≤50 ppm monomethyl ether hydroquinone as inhibitor
C6H10O3
128635
2-Hydroxyethyl methacrylate, contains ≤250 ppm monomethyl ether hydroquinone as inhibitor, 97%
C6H10O3
107700
4-(Dimethylamino)pyridine, ReagentPlus®, ≥99%
C7H10N2
39405
4-(Dimethylamino)pyridine, purum, ≥98.0% (NT)
C7H10N2
714844
4-(Dimethylamino)pyridine solution, 0.5 M in THF
C7H10N2
PHR1317
Residual Solvent - Toluene, Pharmaceutical Secondary Standard; Certified Reference Material
C7H8
87369
Tetrahydrofuran, Selectophore, ≥99.5%
C4H8O
78445
Tetrahydrofuran, analytical standard
C4H8O
PHR1561
Tetrahydrofuran, Pharmaceutical Secondary Standard; Certified Reference Material
C4H8O
S3252
Tin(II) 2-ethylhexanoate, 92.5-100.0%
C16H30O4Sn
89680
Toluene, analytical standard
C7H8
PHR1311
Toluene
C7H8
73487
Triethylamine, analytical standard
C6H15N
68957
Tris(2-carboxyethyl)phosphine hydrochloride, BioUltra, for electrophoresis, SDS-PAGE tested
C9H15O6P · HCl
C4706
Tris(2-carboxyethyl)phosphine hydrochloride, powder
C9H15O6P · HCl
75259
Tris(2-carboxyethyl)phosphine hydrochloride, BioUltra, ≥98% (NMR)
C9H15O6P · HCl
646547
Tris(2-carboxyethyl)phosphine hydrochloride solution, 0.5 M, pH 7.0(aqueous solution; pH was adjusted with ammonium hydroxide)
C9H15O6P · HCl
Y0001099
Valaciclovir impurity G, European Pharmacopoeia (EP) Reference Standard
C7H10N2