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Zhongguo yao li xue bao = Acta pharmacologica Sinica

Biological N-oxidation of piperidine in vitro.


PMID 2609998

Abstract

The biological N-oxidation of piperidine, a pharmacologically active biogenic amine of mammals and human beings, was studied in vitro. After incubation of piperidine-HCl in a fortified rat liver microsomal preparation (9000 x g supernatant) at 37 degrees C for 30 min, 2 metabolites were detected. They were identified as N-hydroxy piperidine and 2, 3, 4, 5-tetrahydro-pyridine-1-oxide as evidenced by TLC, GLC, HPLC, GC-MS and MS.

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56207
1-Hydroxypiperidine, ≥96.0% (GC)
C5H11NO