EMAIL THIS PAGE TO A FRIEND

Scientific reports

Sonorensin: A new bacteriocin with potential of an anti-biofilm agent and a food biopreservative.


PMID 26292786

Abstract

The emergence of antibiotic resistant bacteria has led to exploration of alternative therapeutic agents such as ribosomally synthesized bacterial peptides known as bacteriocins. Biofilms, which are microbial communities that cause serious chronic infections, form environments that enhance antimicrobial resistance. Bacteria in biofilm can be upto thousand times more resistant to antibiotics than the same bacteria circulating in a planktonic state. In this study, sonorensin, predicted to belong to the heterocycloanthracin subfamily of bacteriocins, was found to be effectively killing active and non-multiplying cells of both Gram-positive and Gram-negative bacteria. Sonorensin showed marked inhibition activity against biofilm of Staphylococcus aureus. Fluorescence and electron microscopy suggested that growth inhibition occurred because of increased membrane permeability. Low density polyethylene film coated with sonorensin was found to effectively control the growth of food spoilage bacteria like Listeria monocytogenes and S. aureus. The biopreservative effect of sonorensin coated film showing growth inhibition of spoilage bacteria in chicken meat and tomato samples demonstrated the potential of sonorensin as an alternative to current antibiotics/ preservatives.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

L5501
L-Lysine, ≥98% (TLC)
C6H14N2O2
62840
L-Lysine, crystallized, ≥98.0% (NT)
C6H14N2O2
W384704
L-Lysine, ≥97%
C6H14N2O2