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Chirality

Chiral Pool-Based Synthesis of Naphtho-Fused Isocoumarins.


PMID 26441372

Abstract

A variety of chiral derivatives of benzo[d]naphtho[1,2-b]pyran-6-one were prepared in a single step by Et3 N-mediated condensation of homophthalic anhydride with different derivatives of (S)-amino acid chlorides at -5 °C by employing a chiral pool methodology.