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British journal of haematology

Coagulation activation in sickle cell trait: an exploratory study.


PMID 26511074

Abstract

Recent epidemiologic data suggest that sickle cell trait (HbAS; AS) is a risk factor for venous thromboembolism. We conducted an exploratory study of healthy subjects with AS under baseline conditions to determine whether a chronic basal hyperactivation of coagulation exists, and if so, what mechanism(s) contribute to this state. Eighteen healthy AS individuals were compared to 22 African-American controls with a normal haemoglobin profile (HbAA; AA) and 17 patients with sickle cell disease (HbSS; SS). Plasma thrombin-antithrombin complexes and D-dimer levels were elevated in AS relative to AA patients (Pxa0=xa00·0385 and Pxa0=xa00·017, respectively), and as expected, were much higher in SSversusAA (Pxa0

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