EMAIL THIS PAGE TO A FRIEND

International journal of molecular sciences

Genotoxicity of Superparamagnetic Iron Oxide Nanoparticles in Granulosa Cells.


PMID 26540051

Abstract

Nanoparticles that are aimed at targeting cancer cells, but sparing healthy tissue provide an attractive platform of implementation for hyperthermia or as carriers of chemotherapeutics. According to the literature, diverse effects of nanoparticles relating to mammalian reproductive tissue are described. To address the impact of nanoparticles on cyto- and genotoxicity concerning the reproductive system, we examined the effect of superparamagnetic iron oxide nanoparticles (SPIONs) on granulosa cells, which are very important for ovarian function and female fertility. Human granulosa cells (HLG-5) were treated with SPIONs, either coated with lauric acid (SEONLA) only, or additionally with a protein corona of bovine serum albumin (BSA; SEON(LA-BSA)), or with dextran (SEON(DEX)). Both micronuclei testing and the detection of γH2A.X revealed no genotoxic effects of SEON(LA-BSA), SEON(DEX) or SEON(LA). Thus, it was demonstrated that different coatings of SPIONs improve biocompatibility, especially in terms of genotoxicity towards cells of the reproductive system.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

700312
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size, 5 mg/mL in toluene
Fe3O4
700320
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size, 5 mg/mL in toluene
Fe3O4
700304
Iron oxide(II,III), magnetic nanoparticles solution, 20 nm avg. part. size, 5 mg/mL in toluene
Fe3O4
725331
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size, 5 mg/mL in H2O
Fe3O4
725358
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size, 5 mg/mL in H2O
Fe3O4
725366
Iron oxide(II,III), magnetic nanoparticles solution, 20 nm avg. part. size, 5 mg/mL in H2O
Fe3O4
747327
Iron oxide(II,III), magnetic nanoparticles solution, 30 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H2O, dispersion
Fe3O4
747424
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm diameter, biotin functionalized, 1 mg/mL Fe, dispersion in H2O
Fe3O4
747254
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL Fe in H2O, dispersion
Fe3O4
747343
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H2O, dispersion
Fe3O4
747319
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H2O, dispersion
Fe3O4
747300
Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H2O, dispersion
Fe3O4
747408
Iron oxide(II,III), magnetic nanoparticles solution, 30 nm avg. part. size (TEM), PEG functionalized, dispersion, 1 mg/mL Fe in H2O
Fe3O4
747416
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size (TEM), biotin functionalized, 1 mg/mL Fe in H2O, dispersion
Fe3O4
790508
Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H2O, dispersion
Fe3O4
518158
Iron(II,III) oxide, 99.99% trace metals basis
Fe3O4
637106
Iron(II,III) oxide, nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis
Fe3O4
310069
Iron(II,III) oxide, powder, <5 μm, 95%
Fe3O4