Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro.

PMID 26849573


The aim of this study was to compare the caries-preventive effect of a stabilized stannous fluoride/sodium fluoride dentifrice containing sodium hexametaphosphate with those of a regular, solely sodium fluoride-containing and amine fluoride-containing dentifrice on pre-demineralized bovine enamel specimens using a pH-cycling model. Bovine enamel specimens with two artificial lesions each were prepared. Baseline mineral loss of both lesions was analyzed using transversal microradiography (TMR). Eighty-five specimens with a mean (SD) baseline mineral loss of 3393 (683) vol%xa0×xa0µm were selected and randomly allocated to five groups (nxa0=xa013/15). Treatments during pH-cycling (28xa0days and 2xa0×xa020xa0min demineralization/day) were: brushing twice daily with slurries of AmF (1400xa0ppm F(-)), NaF (1450xa0ppm F(-)), SnF2/NaF (1100xa0ppm F(-)/350xa0ppm F(-)), and fluoride-free (FF) dentifrices or they were immersed in distilled water and remained unbrushed (NB). Subsequently, from each specimen one lesion was covered with acid-resistant varnish, while the remaining lesion was demineralized for another 14xa0days. Differences in integrated mineral loss (∆∆Z) were calculated between values before and after pH-cycling (∆∆Z E1) as well as before pH-cycling and after second demineralization (∆∆Z E2) using TMR. Treatments AmF and NaF induced a significantly higher mineral gain (∆∆Z E1/∆∆Z E2) compared to treatments FF and NB (pxa0